omaveloxolone

Term ID

CHEBI:229661

Synonyms

N-(2-cyano-3,12-dioxo-28-noroleana-1,9(11)-dien-17-yl)-2,2-difluoropropanamide
N-[(4aS,6aR,6bS,8aR,12aS,14aR,14bS)-11-cyano-2,2,6a,6b,9,9,12a-heptamethyl-10,14-dioxo-1,3,4,5,6,6a,6b,7,8,8a,9,10,12a,14,14a,14b-hexadecahydropicen-4a(2H)-yl]-2,2-difluoropropanamide
omaveloxolona
omaveloxolone
omaveloxolonum
RTA 408
RTA-408
RTA408
Skyclarys

Definition

A semi-synthetic triterpenoid drug. It is an Nrf2 activator that is approved for the treatment of Friedreich's ataxia in adults and adolescents aged 16 years and older.

References

cas:1474034-05-3
drugbank:DB12513
kegg.drug:D10964
pubmed:28919776
pubmed:29476889
pubmed:29925185
pubmed:31118567
pubmed:31185608
pubmed:31256292
pubmed:31487581
pubmed:33017422
pubmed:33295701
pubmed:34573098
pubmed:34709651
pubmed:34721761
pubmed:35285087
pubmed:35883884
pubmed:36032663
pubmed:36444905
pubmed:36708320
pubmed:37077825
pubmed:37094050
pubmed:37137161
pubmed:37142519
pubmed:37155124
pubmed:37219716
pubmed:37352984
pubmed:37691319
pubmed:37773082
pubmed:37795909
pubmed:37951537
pubmed:38047307
pubmed:38145457
pubmed:38269532
pubmed:38272714
wikipedia.en:Omaveloxolone

Ontology

ChEBI ( EBI )

Relationships

Phenotype

Phenotype resulting from omaveloxolone

Phenotype where environments contain omaveloxolone

Phenotype modified by environments containing omaveloxolone

Phenotype affecting omaveloxolone

Human Disease Model