Search Ontology:
ChEBI
LCL161
- Term ID
- CHEBI:193137
- Synonyms
-
- (2S)-N-[(1S)-1-cyclohexyl-2-{(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl]-2-(methylamino)propanamide
- (S)-N-((S)-1-cyclohexyl-2-((S)-2-(4-(4-fluorobenzoyl)thiazol-2-yl)pyrrolidin-1-yl)-2-oxoethyl)-2-(methylamino)propanamide
- LCL 161
- LCL-161
- N-[(1S)-1-cyclohexyl-2-{(2S)-2-[4-(4-fluorobenzoyl)-1,3-thiazol-2-yl]pyrrolidin-1-yl}-2-oxoethyl]-N(2)-methyl-L-alaninamide
- NVP-LCL161
- Definition
- LCL161 is a small molecule inhibitor of IAPs that has potent antitumour activity in a range of solid tumours. In HCC, response to LCL161 therapy has shown to be mediated by Bcl-2 expression.
- References
-
- CAS:1005342-46-0
- PMID:22580047
- PMID:24976294
- PMID:26846923
- PMID:27043662
- PMID:27640787
- PMID:27737687
- PMID:29455885
- PMID:30235087
- PMID:30530779
- PMID:31015310
- PMID:31138375
- PMID:31521127
- PMID:31908904
- PMID:32497533
- PMID:34398333
- PMID:34424319
- PMID:34496878
- PMID:35007560
- PMID:35098674
- PMID:36286042
- PMID:36531039
- PMID:36686801
- PMID:37129455
- PMID:37138866
- PMID:37513508
- PMID:37524969
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Show first 5 Terms
Phenotype
Phenotype resulting from LCL161
Phenotype where environments contain LCL161
Phenotype modified by environments containing LCL161
Human Disease / Model Data
Citations