alpha-Neu5Ac-(2->3)-beta-D-Galp-(1->3)-beta-D-GalpNAc-(1->3)-alpha-D-Galp-(1->4)-beta-D-Galp-(1->4)-beta-D-Glcp-(1<->1')-Cer

Term ID

CHEBI:189546

Synonyms

• alpha-Neu5Ac-(2->3)-beta-D-Gal-(1->3)-beta-D-GalNAc-(1->3)-alpha-D-Gal-(1->4)-beta-D-Gal-(1->4)-beta-D-Glc-(1<->1')-ceramide
• NeuAcalpha2-3Galbeta1-3GalNAcbeta1-3Galalpha1-4Galbeta1-4Glcbeta-Cer
• NeuAcalpha2->3Galbeta1->3GalNAcbeta1->3Galalpha1->4Galbeta1->4Glcbeta1->1Cer
• SSEA-4
• SSEA-4 antigen
• SSEA4
• stage-specific embryonic antigen 4
• stage-specific embryonic antigen-4

Definition

A glycotetraosylceramide having N-acetyl-β-D-neuraminyl-(2→3)-β-D-galactosyl-(1→3)-N-acetyl-β-D-galactosaminyl-(1→3)-α-D-galactosyl-(1→4)-β-D-galactosyl-(1→4)-β-D-glucose as the hexasaccharide component. It is overexpressed in some cancers and has been linked to disease progression.

References

• kegg.glycan:G00098
• lipidmaps:LMSP0601AB00
• metacyc.compound:SSEA4
• pubmed:1979319
• pubmed:20683402
• pubmed:22237379
• pubmed:22266579
• pubmed:22743677
• pubmed:23301556
• pubmed:23515456
• pubmed:24279891
• pubmed:24550271
• pubmed:24581260
• pubmed:25978997
• pubmed:26607327
• pubmed:27797400
• pubmed:27836003
• pubmed:28736232
• pubmed:29907955
• pubmed:31243630
• pubmed:31831622
• pubmed:31916611
• pubmed:32691968
• pubmed:32988880
• pubmed:33733429
• pubmed:33945505
• pubmed:34211078
• pubmed:34230128
• pubmed:34369155
• pubmed:34667379
• pubmed:34734786
• pubmed:34876527

Ontology

ChEBI  ( EBI )