palovarotene

Term ID

CHEBI:188559

Synonyms

• 4-{(E)-2-[5,5,8,8-tetramethyl-3-(1H-pyrazol-1-ylmethyl)-5,6,7,8-tetrahydronaphthalen-2-yl]ethenyl}benzoic acid
• CLM 001
• CLM-001
• palovarotene
• palovaroteno
• palovarotenum
• R-667
• R667
• RG-667
• RO 3300074
• RO-3300074
• RO3300074
• Sohonos

Definition

An olefinic compound that is ethene is which a hydrogen at position 1 is replaced by a 4-carboxyphenyl group and a hydrogen at position 2 is replaced by a 5,5,8,8-tetramethyl-3-[(1H-pyrazol-1-yl)methyl]-5,6,7,8-tetrahydronaphthalen-2-yl group (the E-stereoisomer). It is a selective retinoic acid receptor gamma (RARgamma) agonist developed by Ipsen, to reduce the formation of new heterotopic ossification in adults and children with fibrodysplasia ossificans progressiva (FOP), a rare bone disorder.

References

• CAS:410528-02-8
• Chemspider:8470763
• DrugBank:DB05467
• KEGG:D09365
• LINCS:LSM-45512
• PMCID:PMC7208379
• PMID:17324249
• PMID:19876792
• PMID:26896819
• PMID:28960501
• PMID:29120519
• PMID:30226468
• PMID:30698142
• PMID:32245464
• PMID:34831466
• PMID:35384641
• PMID:35530413
• PMID:35638441
• PMID:35646981
• PMID:35802768
• PMID:35854638
• PMID:36052494
• PMID:36542308
• PMID:36583535
• PMID:36802022
• PMID:37643264
• PMID:37796111
• PMID:37804430
• PMID:37934835
• PMID:37957586
• PMID:38130748
• Wikipedia:Palovarotene

Ontology

ChEBI  ( EBI )