Search Ontology:
ChEBI
sotorasib
- Term ID
- CHEBI:178199
- Synonyms
-
- 6-fluoro-7-(2-fluoro-6-hydroxyphenyl)-1-[4-methyl-2-(propan-2-yl)pyridin-3-yl]-4-[(2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl]pyrido[2,3-d]pyrimidin-2(1H)-one
- AMG 510
- AMG-510
- AMG510
- Lumakras
- sotorasib
- sotorasibum
- Definition
- A pyridopyrimidine that is pyrido[2,3-d]pyrimidin-2(1H)-one substituted by 4-methyl-2-(propan-2-yl)pyridin-3-yl, (2S)-2-methyl-4-(prop-2-enoyl)piperazin-1-yl, fluoro and 2-fluoro-6-hydroxyphenyl groups at positions 1, 4, 6 and 7, respectively. It is approved for the treatment of patients with non-small cell lung cancer having KRAS(G12C) mutations.
- References
-
- CAS:2296729-00-3
- Chemspider:72380148
- DrugBank:DB15569
- KEGG:D12055
- PMID:31189530
- PMID:31666701
- PMID:31820981
- PMID:32540954
- PMID:32686745
- PMID:32955176
- PMID:33283304
- PMID:33466360
- PMID:33547148
- PMID:33957355
- PMID:33971321
- PMID:34004237
- PMID:34043291
- PMID:34094546
- PMID:34096690
- PMID:34137282
- PMID:34140669
- PMID:34144959
- PMID:34158284
- PMID:34219153
- PMID:34301758
- PMID:34357500
- PMID:34359807
- Wikipedia:Sotorasib
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
Show All 8 Terms
Show first 5 Terms
Phenotype
Phenotype resulting from sotorasib
Phenotype where environments contain sotorasib
Phenotype modified by environments containing sotorasib
Human Disease / Model Data
Citations