BAY11-7085

Term ID

CHEBI:176500

Synonyms

(2E)-3-(4-tert-butylbenzene-1-sulfonyl)prop-2-enenitrile
(2E)-3-[(4-tert-butylphenyl)sulfonyl]prop-2-enenitrile
(2E)-3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
(E)-3-(4-t-butylphenylsulfonyl)-2-propenenitrile
(E)-3-(4-tert-butylphenylsulfonyl)-2-propenenitrile
Bay 11-7083
Bay 11-7085
Bay-11-7085
BAY-117085

Definition

A sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzenes nitrile sulfone

benzenes nitrile sulfone Show first 5 Terms
has_role: anti-inflammatory agent antibacterial agent antineoplastic agent apoptosis inducer autophagy inducer ... Show All 8 Terms

anti-inflammatory agent antibacterial agent antineoplastic agent apoptosis inducer autophagy inducer EC 2.7.11.10 (IkappaB kinase) inhibitor ferroptosis inducer NF-kappaB inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from BAY11-7085

Phenotype where environments contain BAY11-7085

Phenotype modified by environments containing BAY11-7085

Human Disease / Model Data

Citations