Search Ontology:
ChEBI
STM2457
- Term ID
- CHEBI:172325
- Synonyms
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- N-[(6-{[(cyclohexylmethyl)amino]methyl}imidazo[1,2-a]pyridin-2-yl)methyl]-4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxamide
- STM 2457
- STM-2457
- Definition
- A secondary carboxamide resulting from the formal condensation of the carboxy group of 4-oxo-4H-pyrido[1,2-a]pyrimidine-2-carboxylic acid with the primary amino group of 1-[2-(aminomethyl)imidazo[1,2-a]pyridin-6-yl]-N-(cyclohexylmethyl)methanamine. It is a highly potent and selective first-in-class small molecule inhibitor of METTL3 (N6-adenosine-methyltransferase 70 kDa subunit) enzyme activity and exhibits anti-leukaemic activity.
- References
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- PMID:33902106
- Patent:WO2020201773
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
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Show first 5 Terms
Phenotype
Phenotype resulting from STM2457
Phenotype where environments contain STM2457
Phenotype modified by environments containing STM2457
Human Disease / Model Data
Citations