3-hydroxy-3-methylglutaric acid

Term ID

CHEBI:16831

Synonyms

• (S)-3-Hydroxy-3-methylglutaric acid
• (S)-Meglutol
• 3-HYDROXY-3-METHYL-GLUTARIC ACID
• 3-Hydroxy-3-methylpentanedioic acid
• beta-Hydroxy-beta-methylglutaric acid
• Dicrotalic acid
• meglutol
• meglutolum

Definition

A dicarboxylic acid that is glutaric acid in which one of the two hydrogens at position 3 is substituted by a hydroxy group, while the other is substituted by a methyl group. It has been found to accumulate in urine of patients suffering from HMG-CoA lyase (3-hydroxy-3-methylglutaryl-CoA lyase, EC 4.1.3.4) deficiency. It occurs as a plant metabolite in Crotalaria dura.

References

• cas:503-49-1
• drugbank:DB04377
• drugcentral:1670
• hmdb:HMDB0000355
• kegg.compound:C03761
• kegg.drug:D04897
• knapsack:C00001187
• metacyc.compound:CPD-547
• pdb-ccd:MAH
• pubmed:10916782
• pubmed:17941049
• pubmed:3063529
• pubmed:4717513
• pubmed:6083597
• pubmed:9658458
• reaxys:1769194

Ontology

ChEBI  ( EBI )

Resources

CTD