GSK343

Term ID

CHEBI:167693

Synonyms

1-isopropyl-N-[(6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl]-6-[2-(4-methylpiperazin-1-yl)pyridin-4-yl]-1H-indazole-4-carboxamide
GSK 343
GSK-343

Definition

A member of the class of indazoles that is 1-isopropyl-1H-indazole-4-carboxamide in which the nitrogen of the carboxamide group is substituted by a (6-methyl-2-oxo-4-propyl-1,2-dihydropyridin-3-yl)methyl group and in which the indazole ring is substituted at position 6 by a 2-(4-methylpiperazin-1-yl)pyridin-4-yl group. A highly potent and selective EZH2 inhibitor (IC50 = 4 nM).

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aminopyridine indazoles N-alkylpiperazine N-arylpiperazine pyridone ... Show All 6 Terms

aminopyridine indazoles N-alkylpiperazine N-arylpiperazine pyridone secondary carboxamide Show first 5 Terms
has_role: antineoplastic agent apoptosis inducer EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor

antineoplastic agent apoptosis inducer EC 2.1.1.43 (enhancer of zeste homolog 2) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from GSK343

Phenotype where environments contain GSK343

Phenotype modified by environments containing GSK343

Human Disease / Model Data

Citations