ASP-3026

Term ID

CHEBI:167650

Synonyms

2-N-[2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl]-4-N-(2-propan-2-ylsulfonylphenyl)-1,3,5-triazine-2,4-diamine
ASP 3026
ASP3026
N(2)-[2-methoxy-4-[4-(4-methyl-1-piperazinyl)-1-piperidinyl]phenyl]-N(4)-[2-[(1-methylethyl)sulfonyl]phenyl]-1,3,5-triazine-2,4-diamine
N-{2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl}-N'-[2-(propan-2-ylsulfonyl)phenyl]-1,3,5-triazine-2,4-diamine

Definition

A member of the class of diamino-1,3,5-triazines that is 1,3,5-triazine-2,4-diamine in which the amino groups at positions 2 and 4 are respectively carrying 2-methoxy-4-[4-(4-methylpiperazin-1-yl)piperidin-1-yl]phenyl and 2-(propan-2-ylsulfonyl)phenyl substituents. It is a potent inhibitor of anaplastic lymphoma kinase (ALK), Ack and ROS1 activity (IC50 values are 3.5, 5.8 and 8.9 nM respectively) and exhibits anti-cancer properties.

References

Ontology

ChEBI ( EBI )

Relationships

is a type of: aromatic amine diamino-1,3,5-triazine monomethoxybenzene N-methylpiperazine piperidines ... Show All 7 Terms

aromatic amine diamino-1,3,5-triazine monomethoxybenzene N-methylpiperazine piperidines secondary amino compound sulfone Show first 5 Terms
has_role: antimalarial antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor EC 6.1.1.6 (lysine--tRNA ligase) inhibitor

antimalarial antineoplastic agent apoptosis inducer EC 2.7.10.1 (receptor protein-tyrosine kinase) inhibitor EC 6.1.1.6 (lysine--tRNA ligase) inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from ASP-3026

Phenotype where environments contain ASP-3026

Phenotype modified by environments containing ASP-3026

Human Disease / Model Data

Citations