Search Ontology:
ChEBI
MLN-4760
- Term ID
- CHEBI:166834
- Synonyms
-
- (S,S)-2-(1-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)-ethylamino)-4-methylpentanoic acid
- 2(S)-(1(S)-carboxy-2-(3-(3,5-dichlorobenzyl)-3H-imidazol-4-yl)-ethylamino)-4-methylpentanoic acid
- GL-1001
- GL1001
- MLN4760
- N-[(1S)-1-carboxy-3-methylbutyl]-3-(3,5-dichlorobenzyl)-L-histidine
- N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine
- ORE-1001
- ORE-1001 free acid
- ORE1001
- Definition
- A L-histidine derivative that is L-histidine in which a hydrogen of the primary amino group is substituted by a (1S)-1-carboxy-3-methylbutyl group and the ring NH group is substituted by a 3,5-dichlorobenzyl group. It is a potent and selective human angiotensin-converting enzyme 2 (ACE2) inhibitor (IC50 = 0.44 nM) which was in clinical development for the treatment of ulcerative colitis.
- References
-
- CAS:305335-31-3
- Chemspider:395128
- DrugBank:DB12271
- LINCS:LSM-45511
- PDBeChem:XX5
- PMID:14754895
- PMID:18243695
- PMID:18324760
- PMID:18356558
- PMID:19517214
- PMID:26851370
- PMID:27302421
- PMID:30806090
- PMID:31356776
- PMID:31393582
- PMID:32368013
- PMID:32866470
- PMID:33122196
- Ontology
- ChEBI ( EBI )
- is a type of
-
- has_role
-
Show first 5 Terms
Phenotype
Phenotype resulting from MLN-4760
Phenotype where environments contain MLN-4760
Phenotype modified by environments containing MLN-4760
Human Disease / Model Data
Citations