tomaymycin

Term ID

CHEBI:157681

Synonyms

(11R,11aS)-2-ethylidene-8-hydroxy-7,11-dimethoxy-1,2,3,10,11,11a-hexahydro-5H-pyrrolo[2,1-c][1,4]benzodiazepin-5-one

Definition

A pyrrolobenzodiazepine that is (11aS)-2,3,5,10,11,11a-hexahydro-1H-pyrrolo[2,1-c][1,4]benzodiazepine which is substituted at positions 2,5,7,8 and 11R by ethylidene, oxo, methoxy, hydroxy and methoxy groups, respectively. It is a natural product of Streptomyces achromogenes that binds covalently with guanine in the minor groove of DNA. It is an antitumoral compound which is active in ovarian, plasmacytoma, and leukemia cancer cell lines at nanomolar concentrations.

References

Ontology

ChEBI ( EBI )

Resources

CTD

Relationships

is a type of: aromatic ether olefinic compound phenols pyrrolobenzodiazepine

aromatic ether olefinic compound phenols pyrrolobenzodiazepine Show first 5 Terms
has subtype: (E)-tomaymycin (Z)-tomaymycin

(E)-tomaymycin (Z)-tomaymycin Show first 5 Terms
has_role: alkylating agent antibacterial agent antineoplastic agent bacterial metabolite

alkylating agent antibacterial agent antineoplastic agent bacterial metabolite Show first 5 Terms

Phenotype

Phenotype resulting from tomaymycin

Phenotype where environments contain tomaymycin

Phenotype modified by environments containing tomaymycin

Human Disease / Model Data

Citations