SGC-CLK-1

Term ID

CHEBI:156443

Synonyms

4-(6-methoxypyrazolo[1,5-b]pyridazin-3-yl)-N-[3-methoxy-5-(trifluoromethyl)phenyl]pyrimidin-2-amine

Definition

A pyrazolopyridazine that is pyrazolo[1,5-b]pyridazine which is substituted by a 2-[3-methoxy-5-(trifluoromethyl)anilino]pyrimidin-4-yl group at position 3 and by a methoxy group at position 6. It is a human GSK-3beta, CDK2, CDK4, CLK1, CLK2, and CLK4 kinase inhibitor.

References

PMID:15341487

Ontology

ChEBI ( EBI )

Relationships

is a type of: (trifluoromethyl)benzenes aromatic ether monomethoxybenzene pyrazolopyridazine pyrimidines ... Show All 7 Terms

(trifluoromethyl)benzenes aromatic ether monomethoxybenzene pyrazolopyridazine pyrimidines secondary amino compound substituted aniline Show first 5 Terms
has_role: EC 2.7.11.22 (cyclin-dependent kinase) inhibitor EC 2.7.11.26 (tau-protein kinase) inhibitor EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor

EC 2.7.11.22 (cyclin-dependent kinase) inhibitor EC 2.7.11.26 (tau-protein kinase) inhibitor EC 2.7.12.* [dual-specificity kinases (those acting on Ser/Thr and Tyr residues)] inhibitor Show first 5 Terms

Phenotype

Phenotype resulting from SGC-CLK-1

Phenotype where environments contain SGC-CLK-1

Phenotype modified by environments containing SGC-CLK-1

Human Disease / Model Data

Citations