nelociguat

Term ID

CHEBI:149785

Synonyms

• BAY 60-4552
• BAY-60-4552
• BAY60-4552
• methyl (4,6-diamino-2-{1-[(2-fluorophenyl)methyl]-1H-pyrazolo[3,4-b]pyridin-3-yl}pyrimidin-5-yl)carbamate
• methyl {4,6-diamino-2-[1-(2-fluorobenzyl)-1H-pyrazolo[3,4-b]pyridin-3-yl]pyrimidin-5-yl}carbamate
• nelociguat
• nelociguatum

Definition

A member of the class of pyrazolopyridines that is 1H-pyrazolo[3,4-b]pyridine which is substituted by a 2-fluorobenzyl and 4,6-diamino-5-[(methoxycarbonyl)amino]pyrimidin-2-yl groups at positions 1 and 3, respectively. It is an active metabolite of riociguat and a soluble guanylate cyclase stimulator developed by Bayer for the treatment of erectile dysfunction and heart failure.

References

• CAS:625115-52-8
• PMCID:PMC3313365
• PMCID:PMC3363255
• PMID:21839578
• PMID:22783192
• PMID:23421435
• PMID:24092345
• PMID:25587836
• PMID:27784018
• PMID:28360348
• Patent:WO2011073118

Ontology

ChEBI  ( EBI )