Search Ontology:
ChEBI
lorlatinib
- Term ID
- CHEBI:143117
- Synonyms
-
- (10R)-7-amino-12-fluoro-2,10,16-trimethyl-15-oxo-10,15,16,17-tetrahydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecine-3-carbonitrile
- loratinib
- Lorbrena
- lorlatinib
- lorlatinibum
- PF-06463922
- PF06463922
- PFE-PKIS 10
- Definition
- A cyclic ether that is 16,17-dihydro-2H-8,4-(metheno)pyrazolo[4,3-h][2,5,11]benzoxadiazacyclotetradecin-15(10H)-one substituted by methyl groups at positions 2 and 10R, and by cyano, amino and fluoro groups at positions 3, 7 and 12 respectively. It is a small molecule inhibitor of ALK and ROS1 kinase developed by Pfizer for the treatment of ALK-positive non-small cell lung cancer.
- References
-
- CAS:1454846-35-5
- DrugBank:DB12130
- KEGG:D11012
- PDBeChem:5P8
- PMID:24819116
- PMID:25073473
- PMID:25349124
- PMID:25733882
- PMID:26698910
- PMID:26880581
- PMID:27413712
- PMID:28594000
- PMID:29744867
- PMID:30413378
- PMID:30478428
- PMID:30604291
- PMID:30816885
- Wikipedia:Lorlatinib
- Ontology
- ChEBI ( EBI )
- is a type of
- has_role
-
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Phenotype
Phenotype resulting from lorlatinib
Phenotype where environments contain lorlatinib
Phenotype modified by environments containing lorlatinib
Human Disease / Model Data
Citations