omega-conotoxin MVIIA

Term ID

CHEBI:142406

Synonyms

• omega-Conopeptide MVIIA (Conus)
• SNX-111
• ziconotide

Definition

A heterodetic cyclic polypeptide consisting of the linear sequence Cys-Lys-Gly-Lys-Gly-Ala-Lys-Cys-Ser-Arg-Leu-Met-Tyr-Asp-Cys-Cys-Thr-Gly-Ser-Cys-Arg-Ser-Gly-Lys-Cys-NH₂ with three disulfide bridges between cysteine residues 1-16, 8-20 and 15-25. A neuronal N-type Ca²⁺ channel blocker in mammalian and amphibian brain, it blocks release of GABA and glutamate at neuronal synapses. Used as a probe for calcium channel receptors, it is selective for different receptor subtypes. A synthetic form, named ziconotide, is an atypical analgesic agent for the amelioration of severe and chronic pain.

References

• cas:107452-89-1
• drugcentral:2878
• pubmed:16503054
• pubmed:17207931
• pubmed:24397285
• pubmed:26662374
• pubmed:26861472
• pubmed:28648727
• pubmed:29440821
• pubmed:29635804
• pubmed:30137539
• pubmed:30206508

Ontology

ChEBI  ( EBI )