aspirin-based probe AP

Term ID

CHEBI:141699

Synonyms

2-(1,3-benzothiazol-2-yl)-4-fluorophenyl 2-(acetyloxy)benzoate
2-(1,3-benzothiazol-2-yl)-4-fluorophenyl 2-acetoxybenzoate
2-(1,3-benzothiazol-2-yl)-4-fluorophenyl salicylate
probe AP

Definition

A benzoate ester resulting from the formal condensation of the carboxy group of acetylsalicylic acid with the phenolic hydroxy group of 2-(1,3-benzothiazol-2-yl)-4-fluorophenol. The latter is a fluorophore which is to the aspirin moiety via an H2O2-responsive bond. It can be used as probe for imaging H2O2 (overproduction of H2O2 causes oxidative stress and is characteristic of vascular diseases). In contrast to arylboronat-based probes, it shows high specificity for H2O2 over peroxynitrite (which is much more reactive than H2O2, but exists at much lower abundance).

References

PMID:29109778

Ontology

ChEBI ( EBI )

Relationships

is a type of: benzoate ester benzothiazoles monofluorobenzenes salicylates

benzoate ester benzothiazoles monofluorobenzenes salicylates Show first 5 Terms
has_functional_parent: 2-(1,3-benzothiazol-2-yl)-4-fluorophenol acetylsalicylic acid

2-(1,3-benzothiazol-2-yl)-4-fluorophenol acetylsalicylic acid Show first 5 Terms
has_role: pharmaceutical

pharmaceutical Show first 5 Terms

Phenotype

Phenotype resulting from aspirin-based probe AP

Phenotype where environments contain aspirin-based probe AP

Phenotype modified by environments containing aspirin-based probe AP

Human Disease / Model Data

Citations