tyloxapol

Term ID

CHEBI:141517

Synonyms

• 4-(1,1,2,2-tetramethylbutyl)phenol polyer with formaldehyde and oxirane
• Alevaire
• oxyethylated tertiary octylphenol formaldehyde polymer
• p-(1,1,3,3-tetramethylbutyl)phenol polymer with ethylene oxide and formaldehyde
• p-isooctylpolyoxyethylenenphenol formaldehyde polymer
• Superinone
• tiloxapol
• Triton A-20
• Triton WR-1339
• tyloxapol
• tyloxapolum
• tyloxypal

Definition

A polymeric compound resulting from the reaction of 4-(1,1,3,3-tetramethylbutyl)phenol with formaldehyde to give a chain in which 6-8 molecules are linked together by CH2 groups ortho to the phenolic hydroxy groups, which have then undergone reaction with oxirane to give polyoxyethyleneoxy moieties, Ar(OCH2CH2)xOH, where x = 8-10. A nonionic liquic polymer, it inhibits lipoprotein lipase and hence clearance of triglyceride from the plasma, so is used to induce hyperlipidaemia in test animals. Also used as a surfactant to aid liquefaction and removal of mucus- and pus-containing bronchopulmonary secretions.

References

• CAS:25301-02-4
• DrugBank:DB06439
• Drug_Central:4738
• KEGG:D03261
• PMID:16779702
• PMID:25182386
• PMID:26949944
• PMID:27308826
• PMID:27504278
• PMID:27558168
• PMID:28432556
• PMID:28684216
• PMID:28961514
• PMID:30182365
• PMID:30270241
• Patent:EP0602702
• Patent:US2454541
• Wikipedia:Tyloxapol

Ontology

ChEBI  ( EBI )

Resources

CTD