Search Ontology:
ChEBI
rubimaillin
- Term ID
- CHEBI:141063
- Synonyms
-
- methyl 6-hydroxy-2,2-dimethyl-2H-benzo[h]chromene-5-carboxylate
- mollugin
- Definition
- A benzochromene that is 2H-benzo[h]chromene which is substituted by two methyl groups at position 2, a methoxycarbonyl group at position 5, and a hydroxy group at position 6. Found in the Chinese medical plant Rubia cordifola, It has an anti-cancer effect by inhibition of TNF-α-induced NF-κB activation. It is also a dual inhibitor of acyl-CoA:cholesterol acyltransferase 1 and 2 (ACAT1 and ACAT2), but is more selective for the ACAT2 isozyme.
- References
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- cas:55481-88-4
- pubmed:19652367
- pubmed:19716835
- pubmed:19765578
- pubmed:21077262
- pubmed:21236252
- pubmed:22997839
- pubmed:23000442
- pubmed:23065756
- pubmed:23318249
- pubmed:23466342
- pubmed:23738323
- pubmed:23845549
- pubmed:24887566
- pubmed:25310176
- pubmed:25636867
- pubmed:26126771
- pubmed:26681510
- pubmed:26697688
- pubmed:27258244
- pubmed:28933726
- pubmed:29027119
- Ontology
- ChEBI ( EBI )
- Resources
- CTD
Phenotype
Phenotype resulting from rubimaillin
Phenotype where environments contain rubimaillin
Phenotype modified by environments containing rubimaillin
Phenotype affecting rubimaillin
Human Disease Model