sepantronium bromide

Term ID

CHEBI:139608

Synonyms

• 1-(2-methoxyethyl)-2-methyl-4,9-dioxo-3-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
• 3-(2-methoxyethyl)-2-methyl-4,9-dioxo-1-(pyrazin-2-ylmethyl)-4,9-dihydro-1H-naphtho[2,3-d]imidazol-3-ium bromide
• bromure de sepantronium
• bromuro de sepantronio
• sepantronii bromidum
• sepantronium bromide
• YM 155
• YM-155

Definition

An organic bromide salt consisting of sepantronium cations and bromide anions. It has been found to selectively inhibit survivin (BIRC5) gene promoter activity and to down-regulate survivin in vitro, so leading to induction of apoptosis.

References

• CAS:781661-94-7
• KEGG:D10164
• PMID:22787117
• PMID:22806304
• PMID:22842455
• PMID:22892872
• PMID:23138529
• PMID:23325792
• PMID:23740602
• PMID:23857959
• PMID:24297644
• PMID:24432379
• PMID:24518133
• PMID:24993306
• PMID:25033765
• PMID:25296978
• PMID:25533314
• PMID:25659731
• PMID:25955434
• PMID:26023798
• PMID:26090615
• PMID:26547260
• PMID:26857688
• PMID:27151995
• PMID:27271121
• PMID:27754993
• PMID:28618939
• Patent:EP2127652
• Patent:US7618992

Ontology

ChEBI  ( EBI )