nebivolol hydrochloride

Term ID

CHEBI:132912

Synonyms

(1RS,1'RS)-1,1'-((2RS,2'SR)-bis(6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl))-2,2'-iminodiethanol hydrochloride
nebivolol monohydrochloride
R 67555
R-67555
rac-(1R)-1-[(2S)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-({(2R)-2-[(2R)-6-fluoro-3,4-dihydro-2H-1-benzopyran-2-yl]-2-hydroxyethyl}amino)ethan-1-ol hydrochloride

Definition

A racemate consisting of equal amounts of (R,S,S,S)- and (S,R,R,R)-nebivolol hydrochloride. A cardioselective beta-blocker, it has vasodilatory activity but lacks intrinsic sympathomimetic and membrane-stabilising activity. It is used as the hydrochloride salt for the management of hypertension, and as an adjunct to standard therapy in elderly patients with stable chronic heart failure.

References

CAS:152520-56-4
KEGG:D06622
Reaxys:4790735
Wikipedia:Nebivolol

Ontology

ChEBI ( EBI )

Relationships

is a type of: racemate

racemate Show first 5 Terms
has_part: (R,S,S,S)-nebivolol hydrochloride (S,R,R,R)-nebivolol hydrochloride

(R,S,S,S)-nebivolol hydrochloride (S,R,R,R)-nebivolol hydrochloride Show first 5 Terms
has_role: antihypertensive agent beta-adrenergic antagonist vasodilator agent

antihypertensive agent beta-adrenergic antagonist vasodilator agent Show first 5 Terms
inverse has_part: Byvalson

Byvalson Show first 5 Terms

Phenotype

Phenotype resulting from nebivolol hydrochloride

Phenotype where environments contain nebivolol hydrochloride

Phenotype modified by environments containing nebivolol hydrochloride

Human Disease / Model Data

Citations