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General Information
ZIRC
OBO ID: GO:1990303
Term Name: UBR1-RAD6 ubiquitin ligase complex Search Ontology:
Synonyms:
  • UBR1-RAD6 complex
Definition: A ubiquitin ligase complex consisting of UBR1 and RAD6 components. It polyubiquitinates proteins containing non-acetylated N-terminal residues causing their subsequent degradation by the proteasome as part of the Ac/N-End Rule pathway. It recognizes non-acetylated N-terminal methionine if it is followed by a hydrophobic residue. Additionally, it acts in an N-end rule independent manner as a component of a novel quality control pathway for proteins synthesized on cytosolic ribosomes.19531475
References:
  • IntAct:EBI-9103673
Ontology: GO: Cellular Component   QuickGO   AmiGO
EXPRESSION No data available
PHENOTYPE No data available