| Term Name: |
5-methylcytosine dioxygenase activity |
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Search Ontology:
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| Synonyms: |
- methylcytosine dioxygenase activity
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| Definition: |
Catalysis of the reaction: 5-methylcytosine (5mC) in DNA + 2-oxoglutarate + O2 = 5-hydroxymethylcytosine (5hmC) in DNA + succinate + CO2. This reaction is the first step in the removal of cytosine methylated on position 5 in double-stranded DNA. This activity can iteratively oxidize 5hmC to 5-formylcytosine (5fC) and to 5-carboxylcytosine (5caC).
(3)
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| References: |
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| Ontology: |
GO: Molecular Function
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AmiGO
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