OBO ID: GO:0030374

Term Name:	nuclear receptor coactivator activity		Search Ontology:
Synonyms:	ligand-activated RNA polymerase II transcription factor binding transcription factor activity ligand-dependent nuclear receptor transcription co-activator activity ligand-dependent nuclear receptor transcription coactivator activity nuclear receptor transcription coactivator activity transcription factor activity, ligand-activated RNA polymerase II transcription factor binding
Definition:	A transcription coactivator activity that activates or increases the transcription of specific gene sets via binding to a DNA-bound nuclear receptor, either on its own or as part of a complex. Coactivators often act by altering chromatin structure and modifications. For example, one class of transcription coregulators modifies chromatin structure through covalent modification of histones. A second class remodels the conformation of chromatin in an ATP-dependent fashion. A third class modulates interactions of DNA-bound DNA-binding transcription factors with other transcription coregulators. A fourth class of coactivator activity is the bridging of a DNA-binding transcription factor to the general (basal) transcription machinery. The Mediator complex, which bridges sequence-specific DNA binding transcription factors and RNA polymerase, is also a transcription coactivator.
References:
Ontology:	GO: Molecular Function    QuickGO    AmiGO