Term Name: |
fatty acid elongase activity |
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Search Ontology:
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Synonyms: |
- condensing enzyme
- elongation of very long chain fatty acids activity
- ELOVL
- very-long-chain 3-ketoacyl-CoA synthase
- very-long-chain 3-oxoacyl-CoA synthase
- very-long-chain beta-ketoacyl-CoA synthase
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Definition: |
Catalysis of the reaction: a very-long-chain acyl-CoA + H+ + malonyl-CoA = a very-long-chain 3-oxoacyl-CoA + CO2 + CoA. This reaction is the first (condensation) step of the four-step fatty acid elongation cycle in the endoplasmic reticulum that extends fatty acids of C-16 or longer with an additional 2-C unit.
(2)
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References: |
- EC:2.3.1.199
- MetaCyc:RXN-7697
- RHEA:32727
- Reactome:R-HSA-2046083
- Reactome:R-HSA-2046088
- Reactome:R-HSA-2046090
- Reactome:R-HSA-2046094
- Reactome:R-HSA-2046095
- Reactome:R-HSA-2046100
- Reactome:R-HSA-548800
- Reactome:R-HSA-548814
- Reactome:R-HSA-548815
- Reactome:R-HSA-548830
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Ontology: |
GO: Molecular Function
QuickGO
AmiGO
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