OBO ID: GO:0004489

Term Name:	methylenetetrahydrofolate reductase (NAD(P)H) activity		Search Ontology:
Synonyms:	5,10-CH(2)-H(4)folate reductase activity 5,10-CH2-H4folate reductase activity 5,10-methylenetetrahydrofolate reductase (FADH(2)) activity 5,10-methylenetetrahydrofolate reductase (FADH) activity 5,10-methylenetetrahydrofolate reductase (FADH2) activity 5,10-methylenetetrahydrofolate reductase (NADPH) activity 5,10-methylenetetrahydrofolate reductase activity 5,10-methylenetetrahydrofolic acid reductase activity 5,10-methylenetetrahydropteroylglutamate reductase activity 5-methyltetrahydrofolate:(acceptor) oxidoreductase activity 5-methyltetrahydrofolate:NAD oxidoreductase activity 5-methyltetrahydrofolate:NAD(+) oxidoreductase activity 5-methyltetrahydrofolate:NAD(P)+ oxidoreductase activity 5-methyltetrahydrofolate:NAD+ oxidoreductase activity 5-methyltetrahydrofolate:NADP(+) oxidoreductase activity 5-methyltetrahydrofolate:NADP+ oxidoreductase activity MetF methylenetetrahydrofolate (reduced nicotinamide adenine dinucleotide phosphate) reductase activity methylenetetrahydrofolate (reduced riboflavin adenine dinucleotide) reductase activity methylenetetrahydrofolate reductase (NADPH(2)) activity methylenetetrahydrofolate reductase (NADPH2) methylenetetrahydrofolate reductase [NAD(P)H] methylenetetrahydrofolate reductase activity methylenetetrahydrofolic acid reductase activity MTHFR activity N(5),N(10)-methylenetetrahydrofolate reductase activity N(5,10)-methylenetetrahydrofolate reductase activity N5,10-methylenetetrahydrofolate reductase activity N5,N10-methylenetetrahydrofolate reductase activity
Definition:	Catalysis of the reaction: 5-methyltetrahydrofolate + NAD(P)+ = 5,10-methylenetetrahydrofolate + NAD(P)H + H+. (2)
References:	EC:1.5.1.20 KEGG_REACTION:R01224 KEGG_REACTION:R07168 MetaCyc:1.5.1.20-RXN Reactome:R-HSA-200676
Ontology:	GO: Molecular Function    QuickGO    AmiGO