OBO ID: CHEBI:78543
Term Name: ponatinib Search Ontology:
Synonyms:
  • 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methyl-N-{4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)phenyl}benzamide
  • AP 24534
  • AP-24534
  • AP24534
  • ponatinib
  • ponatinibum
Definition: A benzamide obtained by the formal condensation of the carboxy group of 3-(imidazo[1,2-b]pyridazin-3-ylethynyl)-4-methylbenzoic acid with the anilino group of 4-[(4-methylpiperazin-1-yl)methyl]-3-(trifluoromethyl)aniline. It is a multi-target tyrosine kinase inhibitor that targets ABL, SRC, FGFR, and others and was designed to overcome the resistance of BCR-ABL mutation to imatinib, in particular the gatekeeper mutation ABL(T315I).
References:
Ontology: ChEBI  ( EBI )
Relationships
is a type of:
has_role:
inverse is_conjugate_acid_of:
is_conjugate_base_of:
PHENOTYPE No data available

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