OBO ID: CHEBI:74498
Term Name: 5-fluoroorotic acid Search Ontology:
Synonyms:
  • 1,2,3,6-tetrahydro-2,6-dioxo-5-fluoro-4-pyrimidinecarboxylic acid
  • 5-fluoro-1,2,3,6-tetrahydro-2,6-dioxo-4-pyrimidinecarboxylic acid
  • 5-fluoro-2,6-dioxo-1,2,3,6-tetrahydropyrimidine-4-carboxylic acid
  • 5-fluoro-6-carboxyuracil
  • 5-fluorouracil-4-carboxylic acid
  • ENT-26398
  • FO
  • FOA
  • NSC 31712
  • NSC-31712
  • Ro 2-9945
Definition: A pyrimidinemonocarboxylic that is orotic acid which is substituted by fluorine at position 5. It is used in yeast molecular genetics to detect expression of the URA3 gene, which encodes orotine-5'-monophosphate dicarboxylase. A yeast with and active URA3 gene converts 5-fluoroorotic acid to fluorodeoxyuridine, which is toxic to cells.
References:
Ontology: Chebi
PHENOTYPE No data available