ZFIN ChEBI: retaspimycin

OBO ID: CHEBI:71975

Term Name:	retaspimycin		Search Ontology:
Synonyms:	(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-19-(allylamino)-13,20,22-trihydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3-oxo-2-azabicyclo[16.3.1]docosa-1(22),4,6,10,18,20-hexaen-9-yl carbamate retaspimycin
Definition:	An ansamycin that is tanespimycin in which the benzoquinone moiety has been reduced to the corresponding hydroquinone. A semi-synthetic analogue of geldanamycin, it is used (generally as the hydrochloride salt) in cancer treatment.
References:	CAS:857402-23-4 KEGG:D09375 Patent:US2006205705 Patent:US2008255080 Patent:WO2005063714 Patent:WO2005095347 Patent:WO2007002093 Patent:WO2010135426 Reaxys:11329862
Ontology:	ChEBI ( EBI )

Relationships

is a type of:	ansamycin carbamate ester hydroquinones organic heterobicyclic compound secondary amino compound ... Show All 6 Terms ansamycin carbamate ester hydroquinones organic heterobicyclic compound secondary amino compound semisynthetic derivative Show first 5 Terms
has_functional_parent:	geldanamycin geldanamycin Show first 5 Terms
has_role:	antineoplastic agent Hsp90 inhibitor antineoplastic agent Hsp90 inhibitor Show first 5 Terms
inverse is_conjugate_acid_of:	retaspimycin(1+) retaspimycin(1+) Show first 5 Terms
is_conjugate_base_of:	retaspimycin(1+) retaspimycin(1+) Show first 5 Terms

PHENOTYPE No data available