OBO ID: CHEBI:64153

Term Name:	tanespimycin		Search Ontology:
Synonyms:	(4E,6Z,8S,9S,10E,12S,13R,14S,16R)-13-hydroxy-8,14-dimethoxy-4,10,12,16-tetramethyl-3,20,22-trioxo-19-(prop-2-en-1-ylamino)-2-azabicyclo[16.3.1]docosa-1(21),4,6,10,18-pentaen-9-yl carbamate 17-(Allylamino)-17-demethoxygeldanamycin 17-(Allylamino)geldanamycin 17-AAG 17-allylaminogeldanamycin 17-demethoxy-17-(2-propenylamino)geldanamycin 17-Demethoxy-17-allylamino geldanamycin 17-N-allylamino-17-demethoxygeldanamycin 17AAG NSC 330507 NSC-330507 tanespimycin tanespimycina tanespimycine tanespimycinum
Definition:	A 19-membered macrocyle that is geldanamycin in which the methoxy substituent attached to the benzoquinone moiety has been replaced by an allylamino group. It is a potent inhibitor of heat shock protein 90 (Hsp90). A less toxic analogue than geldanamycin, it induces apoptosis and displays antitumour effects.
References:	CAS:75747-14-7 KEGG:D06650 PMID:20646760 PMID:20652703 PMID:20683637 PMID:21219297 PMID:21283735 PMID:21454186 PMID:21534941 PMID:21558407 PMID:21594721 PMID:21670086 PMID:21791475 PMID:21856392 PMID:22047770 PMID:22209975 PMID:22377218 PMID:22621282 PMID:23564374 PMID:24317439 PMID:25096912 PMID:25633180 PMID:25952464 PMID:26277605 PMID:26408708 PMID:26872308 PMID:26913406 PMID:26922527 PMID:27045471 Reaxys:7402240 Wikipedia:17-N-Allylamino-17-demethoxygeldanamycin
Ontology:	ChEBI  ( EBI )