Term Name: |
8-bromo-3',5'-cyclic GMP |
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Search Ontology:
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Synonyms: |
- 8-Br-cGMP
- 8-Br-Cyclic GMP
- 8-Bromo-cgmp
- 8-Bromocyclic GMP
- 8-Bromocyclic guanosine monophosphate
- 8-bromoguanosine 3',5'-(hydrogen phosphate)
- 8-Bromoguanosine 3',5'-cyclic monophosphate
- 8-Bromoguanosine 3',5'-monophosphate
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Definition: |
A 3',5'-cyclic purine nucleotide that is 3',5'-cyclic GMP bearing an additional bromo substituent at position 8 on the guanine ring. A membrane permeable cGMP analogue that activates protein kinase G (PKG). It is 4.3-fold more potent than cGMP in activating PKG1alpha and promotes relaxation of tracheal and vascular smooth muscle tissue in vitro.
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References: |
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Ontology: |
ChEBI
(
EBI
)
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