OBO ID: CHEBI:567361
Term Name: cladribine Search Ontology:
Synonyms:
  • (2R,3S,5R)-5-(6-amino-2-chloropurin-9-yl)-2-(hydroxymethyl)oxolan-3-ol
  • 2-CdA
  • 2-chloro-2'-deoxy-beta-adenosine
  • 2-chloro-2'-deoxyadenosine
  • 2-chloro-6-amino-9-(2-deoxy-beta-D-erythro-pentofuranosyl)purine
  • 2-chloro-deoxyadenosine
  • 2-chlorodeoxyadenosine
  • 2ClAdo
  • cladribina
  • Cladribine
  • cladribinum
  • CldAdo
Definition: 2'-Deoxyadenosine in which the hydrogen at position 2 on the purine ring has been substituted by chlorine. It inhibits the synthesis and repair of DNA, particularly in lymphocytes and monocytes, and is used as an antimetabolite antineoplastic drug for the treatment of lymphoid malignancies including hairy-cell leukaemia and chronic lymphocytic leukaemia.
References:
Ontology: Chebi
PHENOTYPE No data available