Term Name: |
edrophonium |
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Search Ontology:
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Synonyms: |
- (3-hydroxyphenyl)dimethylethylammonium
- 3-hydroxy-N,N-dimethyl-N-ethylanilinium
- edrophonium
- EDROPHONIUM ION
- Ethyl-(3-hydroxy-phenyl)-dimethyl-ammonium
- N-ethyl-3-hydroxy-N,N-dimethylanilinium
- N-ethyl-3-hydroxy-N,N-dimethylbenzenaminium
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Definition: |
A quaternary ammonium ion that is N-ethyl-N,N-dimethylanilinium in which one of the meta positions is substituted by a hydroxy group. It is a reversible inhibitor of cholinesterase, with a rapid onset (30-60 seconds after injection) but a short duration of action (5-15 minutes). The chloride salt is used in myasthenia gravis both diagnostically and to distinguish between under- or over-treatment with other anticholinesterases. It has also been used for the reversal of neuromuscular blockade in anaesthesia, and for the management of poisoning due to tetrodotoxin, a neuromuscular blocking toxin found in puffer fish and other marine animals.
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References: |
- Beilstein:3905622
- CAS:312-48-1
- DrugBank:DB01010
- Drug_Central:988
- KEGG:C06976
- LINCS:LSM-5867
- PDBeChem:EDR
- PMID:7488499
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Ontology: |
ChEBI
(
EBI
)
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