OBO ID: CHEBI:176500
Term Name: BAY11-7085 Search Ontology:
Synonyms:
  • (2E)-3-(4-tert-butylbenzene-1-sulfonyl)prop-2-enenitrile
  • (2E)-3-[(4-tert-butylphenyl)sulfonyl]prop-2-enenitrile
  • (2E)-3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
  • (E)-3-(4-t-butylphenylsulfonyl)-2-propenenitrile
  • (E)-3-(4-tert-butylphenylsulfonyl)-2-propenenitrile
  • Bay 11-7083
  • Bay 11-7085
  • Bay-11-7085
  • BAY-117085
Definition: A sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB.
References:
Ontology: Chebi
PHENOTYPE No data available