Term Name: |
BAY11-7085 |
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Search Ontology:
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Synonyms: |
- (2E)-3-(4-tert-butylbenzene-1-sulfonyl)prop-2-enenitrile
- (2E)-3-[(4-tert-butylphenyl)sulfonyl]prop-2-enenitrile
- (2E)-3-[[4-(1,1-dimethylethyl)phenyl]sulfonyl]-2-propenenitrile
- (E)-3-(4-t-butylphenylsulfonyl)-2-propenenitrile
- (E)-3-(4-tert-butylphenylsulfonyl)-2-propenenitrile
- Bay 11-7083
- Bay 11-7085
- Bay-11-7085
- BAY-117085
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Definition: |
A sulfone that is benzene substituted by [(E)-2-cyanoethenyl]sulfonyl and tert-butyl groups at position 1 and 4, respectively. It is an irreversible inhibitor of IkappaB-alpha phosphorylation in cells (IC50 = 10 muM) and prevents the activation of NF-kappaB.
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References: |
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Ontology: |
ChEBI
(
EBI
)
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