| Term Name: |
1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-o-tolylurea |
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Search Ontology:
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| Synonyms: |
- 1-(4-(3-amino-1H-indazol-4-yl)phenyl)-3-o-tolylurea
- 1-[4-(3-amino-1H-indazol-4-yl)phenyl]-3-(2-methylphenyl)urea
- N-[4-(3-amino-1H-indazol-4-yl)phenyl]-N''-(2-methylphenyl)-urea
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| Definition: |
A member of the class of indazoles that is linifanib in which the 2-fluoro-5-methylphenyl group has been replaced by a 2-methylphenyl group. A cell-permeable 3-aminoindazolylurea compound, it acts as a potent and ATP-competitive inhibitor of VEGFR2/KDR (IC50 = 3 nM) as well as Flt3 and cKit (IC50 = 4 to 20 nM). Shown to block VEGF-induced VEGFR2 phosphorylation in 3T3-murine fibroblasts in vitro.
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| References: |
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| Ontology: |
ChEBI
(
EBI
)
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