ZFIN Post-Composed Term: Muller cell cell surface receptor signaling pathway via JAK-STAT

Term:	Muller cell cell surface receptor signaling pathway via JAK-STAT
Note:	This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name.

Name:	Muller cell
Synonyms:	Mueller cell, Muller cells
Definition:	Glial cell of the retina that forms a support structure stretching radially across the thickness of the retina. Muller cell bodies are found in the inner nuclear layer and send projection to the outer limiting membrane and inner limiting membrane.
Ontology:	Anatomy Ontology [ZFA:0009280]

Name:	cell surface receptor signaling pathway via JAK-STAT
Synonyms:	JAK-STAT cascade, JAK-STAT signal transduction, receptor signaling pathway via JAK-STAT
Definition:	A cell surface receptor signaling pathway in which ligand binding causes the receptor to dimerize, bringing the receptor-associated JAKs into close proximity. The JAKs then phosphorylate and activate each other on tyrosine residues.This leads to the activation of associated STAT protein, causing the STATs to dissociate from the receptor, translocate to the nucleus. The pathway ends with regulation of target gene expression by STAT proteins.
Ontology:	GO: Biological Process [GO:0007259] QuickGO AmiGO