| Name: |
hippo signaling |
| Synonyms: |
hippo signal transduction,
hippo signaling cascade,
hippo signaling pathway,
hippo signalling cascade,
Salvador-Warts-Hippo signaling pathway,
SWH pathway
|
| Definition: |
An intracellular signaling cascade that starts with the activation of hippo (STK4/MST1 and STK3/MST2 in mammals and hpo kinase in Drosophila). Hippo then phosphorylates LATS1/2, which in turn phosphoylates the transcriptional co-activator YAP1 (yki in Drosophila), leading to its cytosolic retention and/or degradation. |
| Ontology: |
GO: Biological Process [GO:0035329]
QuickGO
AmiGO
|
