Term: exocrine pancreas canonical Wnt signaling pathway
Note: This page represents a term created by the combination ("post-composition") of two ontology terms. For more information on the individual terms, click the hyperlinked name.
Name: exocrine pancreas
Synonyms: head pancreas, rostral pancreas
Definition: The exocrine pancreas is a diffuse organ composed of a branching network of ducts and associated acinar glands that manufacture the proteolytic enzymes and bicarbonate required for digestion.
Ontology: Anatomy Ontology [ZFA:0001249]
Name: canonical Wnt signaling pathway
Synonyms: canonical Wnt receptor signaling pathway, canonical Wnt-activated signaling pathway, frizzled-1 receptor signaling pathway, Wnt receptor signaling pathway through beta-catenin, Wnt receptor signaling pathway via beta-catenin, Wnt receptor signalling pathway through beta-catenin
Definition: The series of molecular signals initiated by binding of a Wnt protein to a frizzled family receptor on the surface of the target cell, followed by propagation of the signal via beta-catenin, and ending with a change in transcription of target genes. In this pathway, the activated receptor signals via downstream effectors that result in the inhibition of beta-catenin phosphorylation, thereby preventing degradation of beta-catenin. Stabilized beta-catenin can then accumulate and travel to the nucleus to trigger changes in transcription of target genes.
Ontology: GO: Biological Process [GO:0060070]   QuickGO   AmiGO