Gene
sema3ab
- ID
- ZDB-GENE-991209-6
- Name
- sema domain, immunoglobulin domain (Ig), short basic domain, secreted, (semaphorin) 3Ab
- Symbol
- sema3ab Nomenclature History
- Previous Names
-
- sema3a2 (1)
- semaZ1b
- Type
- protein_coding_gene
- Location
- Chr: 18 Mapping Details/Browsers
- Description
- Predicted to have chemorepellent activity and semaphorin receptor binding activity. Involved in branching involved in blood vessel morphogenesis; branching morphogenesis of a nerve; and motor neuron axon guidance. Predicted to localize to extracellular space and integral component of plasma membrane. Human ortholog(s) of this gene implicated in hypogonadotropic hypogonadism 16 with or without anosmia. Is expressed in brain; myotome; pharyngeal arch; and somite. Orthologous to human SEMA3A (semaphorin 3A).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 10 figures from 10 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| hypogonadotropic hypogonadism 16 with or without anosmia | Alliance | {Hypogonadotropic hypogonadism 16 with or without anosmia} | 614897 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Domain | IPR001627 | Sema domain |
| Domain | IPR003599 | Immunoglobulin domain subtype |
| Domain | IPR007110 | Immunoglobulin-like domain |
| Domain | IPR016201 | PSI domain |
| Family | IPR027231 | Semaphorin |
| Homologous_superfamily | IPR013783 | Immunoglobulin-like fold |
| Homologous_superfamily | IPR015943 | WD40/YVTN repeat-like-containing domain superfamily |
| Homologous_superfamily | IPR036179 | Immunoglobulin-like domain superfamily |
| Homologous_superfamily | IPR036352 | Sema domain superfamily |
Domain Details Per Protein
| Protein | Length | Immunoglobulin domain subtype | Immunoglobulin-like domain | Immunoglobulin-like domain superfamily | Immunoglobulin-like fold | PSI domain | Sema domain | Sema domain superfamily | Semaphorin | WD40/YVTN repeat-like-containing domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:Q9W686
|
778 |
| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
sema3ab-201
(1)
|
Ensembl | 2,652 nt | ||
| mRNA |
sema3ab-202
(1)
|
Ensembl | 2,704 nt | ||
| mRNA |
sema3ab-203
(1)
|
Ensembl | 2,556 nt |
Interactions and Pathways
No data available
Plasmids
No data available