Gene

ldha

ID

ZDB-GENE-991026-5

Name

lactate dehydrogenase A4

Symbol

ldha Nomenclature History

Previous Names

ldha1 (1)

Type

protein_coding_gene

Location

Chr: 25 Mapping Details/Browsers

Description

Predicted to enable L-lactate dehydrogenase activity. Acts upstream of or within response to hypoxia. Predicted to be located in cytoplasm. Predicted to be active in mitochondrion. Is expressed in several structures, including cardiovascular system; gill; liver; muscle; and nervous system. Orthologous to several human genes including LDHA (lactate dehydrogenase A).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

28 figures from 16 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

MGC:55215 (6 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: No data available
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ldha Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
		Glycogen storage disease XI	612933

Associated With ldha Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Active_site	IPR018177	L-lactate dehydrogenase, active site
Domain	IPR001236	Lactate/malate dehydrogenase, N-terminal
Domain	IPR022383	Lactate/malate dehydrogenase, C-terminal
Family	IPR001557	L-lactate/malate dehydrogenase
Family	IPR011304	L-lactate dehydrogenase
Homologous_superfamily	IPR015955	Lactate dehydrogenase/glycoside hydrolase, family 4, C-terminal
Homologous_superfamily	IPR036291	NAD(P)-binding domain superfamily