Gene
nipsnap1
- ID
- ZDB-GENE-991008-17
- Name
- nipsnap homolog 1 (C. elegans)
- Symbol
- nipsnap1 Nomenclature History
- Previous Names
-
- zgc:153339
- Type
- protein_coding_gene
- Location
- Chr: 5 Mapping Details/Browsers
- Description
- Predicted to enable protein-macromolecule adaptor activity. Involved in mitophagy. Predicted to be active in mitochondrial matrix. Is expressed in several structures, including endoderm; heart; liver; pectoral fin; and pleuroperitoneal region. Used to study Parkinson's disease. Orthologous to human NIPSNAP1 (nipsnap homolog 1).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 2 figures from Princely Abudu et al., 2019
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Princely Abudu et al., 2019
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa14357 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa20352 | Allele with one point mutation | Unknown | Splice Site | ENU | |
| sa26414 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa33542 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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| Targeting Reagent | Created Alleles | Citations |
|---|---|---|
| CRISPR1-nipsnap1 | Princely Abudu et al., 2019 | |
| CRISPR2-nipsnap1 | Princely Abudu et al., 2019 | |
| CRISPR3-nipsnap1 | Princely Abudu et al., 2019 |
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Human Disease
| Human Disease | Fish | Conditions | Citations |
|---|---|---|---|
| Parkinson's disease | uio1Tg + CRISPR1-nipsnap1 + CRISPR2-nipsnap1 + CRISPR3-nipsnap1 | standard conditions | Princely Abudu et al., 2019 |
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Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | Dimeric alpha-beta barrel | NIPSNAP | NipSnap domain-containing protein |
|---|---|---|---|---|
|
UniProtKB:F6NVH9
|
279 |
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| Type | Name | Annotation Method | Has Havana Data | Length (nt) | Analysis |
|---|---|---|---|---|---|
| mRNA |
nipsnap1-201
(1)
|
Ensembl | 1,472 nt |
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Interactions and Pathways
No data available
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-nipsnap1 | polyclonal | IgG | Rabbit |
|
Abcam plc
|
2 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-60F6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:153339 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_131033 (1) | 1481 nt | ||
| Genomic | GenBank:CR933780 (2) | 76732 nt | ||
| Polypeptide | UniProtKB:F6NVH9 (1) | 279 aa |
- Princely Abudu, Y., Pankiv, S., Mathai, B.J., Håkon Lystad, A., Bindesbøll, C., Brenne, H.B., Yoke Wui Ng, M., Thiede, B., Yamamoto, A., Mutugi Nthiga, T., Lamark, T., Esguerra, C.V., Johansen, T., Simonsen, A. (2019) NIPSNAP1 and NIPSNAP2 Act as "Eat Me" Signals for Mitophagy. Developmental Cell. 49(4):509-525.e12
- Mahony, C.B., Pasche, C., Bertrand, J.Y. (2018) Oncostatin M and Kit-Ligand Control Hematopoietic Stem Cell Fate during Zebrafish Embryogenesis. Stem Cell Reports. 10(6):1920-1934
- Bayés, À., Collins, M.O., Reig-Viader, R., Gou, G., Goulding, D., Izquierdo, A., Choudhary, J.S., Emes, R.D., Grant, S.G. (2017) Evolution of complexity in the zebrafish synapse proteome. Nature communications. 8:14613
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Strausberg,R.L., Feingold,E.A., Grouse,L.H., Derge,J.G., Klausner,R.D., Collins,F.S., Wagner,L., Shenmen,C.M., Schuler,G.D., Altschul,S.F., Zeeberg,B., Buetow,K.H., Schaefer,C.F., Bhat,N.K., Hopkins,R.F., Jordan,H., Moore,T., Max,S.I., Wang,J., Hsieh,F., Diatchenko,L., Marusina,K., Farmer,A.A., Rubin,G.M., Hong,L., Stapleton,M., Soares,M.B., Bonaldo,M.F., Casavant,T.L., Scheetz,T.E., Brownstein,M.J., Usdin,T.B., Toshiyuki,S., Carninci,P., Prange,C., Raha,S.S., Loquellano,N.A., Peters,G.J., Abramson,R.D., Mullahy,S.J., Bosak,S.A., McEwan,P.J., McKernan,K.J., Malek,J.A., Gunaratne,P.H., Richards,S., Worley,K.C., Hale,S., Garcia,A.M., Gay,L.J., Hulyk,S.W., Villalon,D.K., Muzny,D.M., Sodergren,E.J., Lu,X., Gibbs,R.A., Fahey,J., Helton,E., Ketteman,M., Madan,A., Rodrigues,S., Sanchez,A., Whiting,M., Madan,A., Young,A.C., Shevchenko,Y., Bouffard,G.G., Blakesley,R.W., Touchman,J.W., Green,E.D., Dickson,M.C., Rodriguez,A.C., Grimwood,J., Schmutz,J., Myers,R.M., Butterfield,Y.S., Krzywinski,M.I., Skalska,U., Smailus,D.E., Schnerch,A., Schein,J.E., Jones,S.J., and Marra,M.A. (2002) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. Proceedings of the National Academy of Sciences of the United States of America. 99(26):16899-903
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