Gene
srfa
- ID
- ZDB-GENE-990714-29
- Name
- serum response factor a
- Symbol
- srfa Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 22 Mapping Details/Browsers
- Description
- Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and serum response element binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II. Located in nucleus. Is expressed in several structures, including adaxial cell; digestive system; musculature system; pericardial region; and pleuroperitoneal region. Human ortholog(s) of this gene implicated in cardiomyopathy and lymphangioleiomyomatosis. Orthologous to human SRF (serum response factor).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 3 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
| Allele | Type | Localization | Consequence | Mutagen | Supplier |
|---|---|---|---|---|---|
| sa3160 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa5694 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa11724 | Allele with one point mutation | Unknown | Premature Stop | ENU | |
| sa24211 | Allele with one point mutation | Unknown | Premature Stop | ENU |
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No data available
Human Disease
Domain, Family, and Site Summary
Domain Details Per Protein
| Protein | Length | MADS-box/MEF2 Transcription Factor | Transcription factor, MADS-box | Transcription factor, MADS-box superfamily |
|---|---|---|---|---|
|
UniProtKB:A0A8M2BLC6
|
482 | |||
|
UniProtKB:A8HAM3
|
539 |
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Interactions and Pathways
| Name | Type | Antigen Genes | Isotype | Host Organism | Assay | Source | Citations |
|---|---|---|---|---|---|---|---|
| Ab1-srfa | polyclonal | Rabbit |
|
Santa Cruz Biotechnology, Inc.
|
3 |
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Plasmids
No data available
No data available
| Relationship | Marker Type | Marker | Accession Numbers | Citations |
|---|---|---|---|---|
| Contained in | BAC | DKEY-250M6 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:55198 | ZFIN Curated Data | |
| Encodes | cDNA | MGC:192699 | ZFIN Curated Data |
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| Type | Accession # | Sequence | Length (nt/aa) | Analysis |
|---|---|---|---|---|
| RNA | RefSeq:NM_001110526 (1) | 2911 nt | ||
| Genomic | GenBank:CR925810 (1) | 151389 nt | ||
| Polypeptide | UniProtKB:A8HAM3 (1) | 539 aa |
- Zhou, C., Li, M., Sun, Y., Sultan, Y., Li, X. (2024) Systematic Identification of Long Noncoding RNAs during Three Key Organogenesis Stages in Zebrafish. International Journal of Molecular Sciences. 25(6):
- Chen, Z., Zhou, Z., Peng, X., Sun, C., Yang, D., Li, C., Zhu, R., Zhang, P., Zheng, L., Tang, C. (2021) Cardioprotective responses to aerobic exercise-induced physiological hypertrophy in zebrafish heart. The journal of physiological sciences : JPS. 71:33
- Luo, J., Jin, F.Q., Yin, M., Jin, Z.G. (2019) Regulation of SRF protein stability by an autophagy-dependent pathway. Biochemical and Biophysical Research Communications. 521(2):279-284
- Wen, Y., Ushio, H. (2017) Ferulic Acid Promotes Hypertrophic Growth of Fast Skeletal Muscle in Zebrafish Model. Nutrients. 9(10)
- D'Aurizio, R., Russo, F., Chiavacci, E., Baumgart, M., Groth, M., D'Onofrio, M., Arisi, I., Rainaldi, G., Pitto, L., Pellegrini, M. (2016) Discovering miRNA Regulatory Networks in Holt-Oram Syndrome Using a Zebrafish Model. Frontiers in bioengineering and biotechnology. 4:60
- Chiavacci, E., D'Aurizio, R., Guzzolino, E., Russo, F., Baumgart, M., Groth, M., Mariani, L., D'Onofrio, M., Arisi, I., Pellegrini, M., Cellerino, A., Cremisi, F., Pitto, L. (2015) MicroRNA 19a replacement partially rescues fin and cardiac defects in zebrafish model of Holt Oram syndrome. Scientific Reports. 5:18240
- Elkon, R., Milon, B., Morrison, L., Shah, M., Vijayakumar, S., Racherla, M., Leitch, C.C., Silipino, L., Hadi, S., Weiss-Gayet, M., Barras, E., Schmid, C.D., Ait-Lounis, A., Barnes, A., Song, Y., Eisenman, D.J., Eliyahu, E., Frolenkov, G.I., Strome, S.E., Durand, B., Zaghloul, N.A., Jones, S.M., Reith, W., Hertzano, R. (2015) RFX transcription factors are essential for hearing in mice. Nature communications. 6:8549
- Lundquist, M.R., Storaska, A.J., Liu, T.C., Larsen, S.D., Evans, T., Neubig, R.R., Jaffrey, S.R. (2014) Redox modification of nuclear actin by MICAL-2 regulates SRF signaling.. Cell. 156(3):563-76
- Jia, Q., Zhang, Q., Zhang, Z., Wang, Y., Zhang, W., Zhou, Y., Wan, Y., Cheng, T., Zhu, X., Fang, X., Yuan, W., and Jia, H. (2013) Transcriptome Analysis of the Zebrafish Model of Diamond-Blackfan Anemia from RPS19 Deficiency via p53-Dependent and -Independent Pathways. PLoS One. 8(8):e71782
- Davis, J.L., Long, X., Georger, M.A., Scott, I.C., Rich, A., and Miano, J.M. (2008) Expression and comparative genomics of two serum response factor genes in zebrafish. The International journal of developmental biology. 52(4):389-396
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