Gene

eya1

ID

ZDB-GENE-990712-18

Name

EYA transcriptional coactivator and phosphatase 1

Symbol

eya1 Nomenclature History

Previous Names

dog eared (1)
dog (1)
wu:fc13c10
zgc:100770

Type

protein_coding_gene

Location

Chr: 24 Mapping Details/Browsers

Description

Predicted to have protein tyrosine phosphatase activity. Involved in adenohypophysis development; otic vesicle morphogenesis; and otolith development. Predicted to localize to nucleus. Human ortholog(s) of this gene implicated in branchiootic syndrome; branchiootorenal syndrome; and branchiootorenal syndrome 1. Is expressed in several structures, including adenohypophyseal placode; brain; ectoderm; head; and lateral line system. Orthologous to human EYA1 (EYA transcriptional coactivator and phosphatase 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

76 figures from 52 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 17 figures from 7 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With eya1 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
branchiootic syndrome	Alliance	Anterior segment anomalies with or without cataract	602588
branchiootic syndrome	Alliance	Branchiootic syndrome 1	602588
branchiootorenal syndrome 1	Alliance	Branchiootorenal syndrome 1, with or without cataracts	113650
		?Otofaciocervical syndrome	166780

Associated With eya1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Domain	IPR006545	EYA domain
Domain	IPR042577	EYA domain, metazoan
Family	IPR028472	Eyes absent family
Homologous_superfamily	IPR038102	EYA domain superfamily

Domain Details Per Protein

Protein	Length	EYA domain	EYA domain, metazoan	EYA domain superfamily	Eyes absent family
UniProtKB:A0A8M3AZ17 InterPro	592
UniProtKB:A0A8M2B9H5 InterPro	586
UniProtKB:A0A8M3AP55 InterPro	613
UniProtKB:A0A8M6YVK2 InterPro	614
UniProtKB:Q6DBY3 InterPro	587
UniProtKB:Q9W6E8 InterPro	609

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	eya1-201 (1) Ensembl	Ensembl	2,179 nt	Select Tool ZFIN BLAST
mRNA	eya1-202 (1) Ensembl	Ensembl	4,414 nt	Select Tool ZFIN BLAST
mRNA	eya1-203 (1) Ensembl	Ensembl	2,229 nt	Select Tool
mRNA	eya1-204 (1) Ensembl	Ensembl	4,447 nt	Select Tool
mRNA	eya1-206 (1) Ensembl	Ensembl	723 nt	Select Tool
mRNA	eya1-207 (1) Ensembl	Ensembl	1,926 nt	Select Tool ZFIN BLAST
ncRNA	eya1-003 (1) Ensembl	Ensembl	778 nt	Select Tool

Interactions and Pathways

No data available

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations