Gene

wif1

ID

ZDB-GENE-990712-17

Name

wnt inhibitory factor 1

Symbol

wif1 Nomenclature History

Previous Names

zgc:110507 (1)

Type

protein_coding_gene

Location

Chr: 4 Mapping Details/Browsers

Description

Predicted to have signaling receptor binding activity. Involved in negative regulation of canonical Wnt signaling pathway and swim bladder development. Predicted to localize to cell surface and extracellular region. Human ortholog(s) of this gene implicated in breast cancer; renal cell carcinoma; and urinary bladder cancer. Is expressed in several structures, including anterior swim bladder bud; nervous system; paraxial mesoderm; pharyngeal arch; and pleuroperitoneal region. Orthologous to human WIF1 (WNT inhibitory factor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

19 figures from 12 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Thisse Expression Data

eu316 (19 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 5 figures from 2 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With wif1 Human Ortholog

No data available

Associated With wif1 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR003306	WIF domain
Family	IPR013309	Wnt inhibitory factor (WIF)-1
Homologous_superfamily	IPR038677	WIF domain superfamily