Gene
melk
- ID
- ZDB-GENE-990603-5
- Name
- maternal embryonic leucine zipper kinase
- Symbol
- melk Nomenclature History
- Previous Names
- Type
- protein_coding_gene
- Location
- Chr: 1 Mapping Details/Browsers
- Description
- Predicted to enable calcium ion binding activity; non-membrane spanning protein tyrosine kinase activity; and protein serine/threonine kinase activity. Involved in hemopoiesis. Acts upstream of or within erythrocyte development and regulation of heart contraction. Predicted to be located in cell cortex. Predicted to be active in cytoplasm. Is expressed in several structures, including digestive system; immature eye; nervous system; pleuroperitoneal region; and proliferative region. Orthologous to human MELK (maternal embryonic leucine zipper kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 7 figures from 2 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
-
- MGC:56337 (7 images)
Wild Type Expression Summary
- All Phenotype Data
- 4 figures from Saito et al., 2005
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001772 | Kinase associated domain 1 (KA1) |
| Domain | IPR034673 | Maternal embryonic leucine zipper kinase, catalytic domain |
| Domain | IPR048637 | Maternal embryonic leucine zipper kinase, UBA domain |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR028375 | KA1 domain/Ssp2, C-terminal |
Domain Details Per Protein
| Protein | Length | KA1 domain/Ssp2, C-terminal | Kinase associated domain 1 (KA1) | Maternal embryonic leucine zipper kinase, catalytic domain | Maternal embryonic leucine zipper kinase, UBA domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine/threonine-protein kinase, active site |
|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:F1QGZ6
|
676 |
Interactions and Pathways
No data available
Plasmids
No data available