Gene
raf1a
- ID
- ZDB-GENE-990415-41
- Name
- Raf-1 proto-oncogene, serine/threonine kinase a
- Symbol
- raf1a Nomenclature History
- Previous Names
-
- craf
- raf1
- Type
- protein_coding_gene
- Location
- Chr: 23 Mapping Details/Browsers
- Description
- Predicted to enable MAP kinase kinase kinase activity. Acts upstream of or within heart development and regulation of MAPK cascade. Predicted to be located in plasma membrane. Predicted to be active in cytosol and mitochondrion. Is expressed in blastoderm; blastomere; brain; and head. Human ortholog(s) of this gene implicated in Noonan syndrome (multiple); Noonan syndrome with multiple lentigines 2; adenocarcinoma (multiple); and dilated cardiomyopathy 1NN. Orthologous to human RAF1 (Raf-1 proto-oncogene, serine/threonine kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 5 figures from 5 publications
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- 1 Figure from Razzaque et al., 2007
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| dilated cardiomyopathy 1NN | Alliance | Cardiomyopathy, dilated, 1NN | 615916 |
| Noonan syndrome 5 | Alliance | Noonan syndrome 5 | 611553 |
| Noonan syndrome with multiple lentigines 2 | Alliance | LEOPARD syndrome 2 | 611554 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008271 | Serine/threonine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR002219 | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain |
| Domain | IPR003116 | Raf-like Ras-binding |
| Domain | IPR020454 | Diacylglycerol/phorbol-ester binding |
| Family | IPR050167 | Serine/threonine-protein kinase |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR029071 | Ubiquitin-like domain superfamily |
| Homologous_superfamily | IPR046349 | C1-like domain superfamily |
Domain Details Per Protein
| Protein | Length | C1-like domain superfamily | Diacylglycerol/phorbol-ester binding | Protein kinase, ATP binding site | Protein kinase C-like, phorbol ester/diacylglycerol-binding domain | Protein kinase domain | Protein kinase-like domain superfamily | Raf-like Ras-binding | Serine/threonine-protein kinase | Serine/threonine-protein kinase, active site | Serine-threonine/tyrosine-protein kinase, catalytic domain | Ubiquitin-like domain superfamily |
|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:A0A0R4IN14
|
643 | |||||||||||
|
UniProtKB:D3KYU7
|
626 | |||||||||||
|
UniProtKB:A0A8M6Z3N3
|
611 | |||||||||||
|
UniProtKB:A0A8M9PWA5
|
628 |
Interactions and Pathways
Plasmids
No data available
- Comparative Orthology
- Alliance