Gene
itk
- ID
- ZDB-GENE-990415-261
- Name
- IL2 inducible T cell kinase
- Symbol
- itk Nomenclature History
- Previous Names
-
- Ptk
- etID309877.14 (1)
- tec
- ZFPtk
- Type
- protein_coding_gene
- Location
- Chr: 14 Mapping Details/Browsers
- Description
- Predicted to enable non-membrane spanning protein tyrosine kinase activity. Predicted to be involved in NK T cell differentiation; adaptive immune response; and antigen receptor-mediated signaling pathway. Predicted to act upstream of or within immune system process; intracellular signal transduction; and protein phosphorylation. Predicted to be located in cytosol. Predicted to be active in plasma membrane. Human ortholog(s) of this gene implicated in lymphoproliferative syndrome 1. Orthologous to human ITK (IL2 inducible T cell kinase).
- Genome Resources
- Note
- None
- Comparative Information
-
- All Expression Data
- 1 figure from Haire et al., 1998
- Cross-Species Comparison
- High Throughput Data
- Thisse Expression Data
- No data available
Wild Type Expression Summary
- All Phenotype Data
- No data available
- Cross-Species Comparison
- Alliance
Phenotype Summary
Mutations
Human Disease
| Disease Ontology Term | Multi-Species Data | OMIM Term | OMIM Phenotype ID |
|---|---|---|---|
| lymphoproliferative syndrome 1 | Alliance | Lymphoproliferative syndrome 1 | 613011 |
Domain, Family, and Site Summary
| Type | InterPro ID | Name |
|---|---|---|
| Active_site | IPR008266 | Tyrosine-protein kinase, active site |
| Binding_site | IPR017441 | Protein kinase, ATP binding site |
| Conserved_site | IPR001562 | Zinc finger, Btk motif |
| Domain | IPR000719 | Protein kinase domain |
| Domain | IPR000980 | SH2 domain |
| Domain | IPR001245 | Serine-threonine/tyrosine-protein kinase, catalytic domain |
| Domain | IPR001452 | SH3 domain |
| Domain | IPR001849 | Pleckstrin homology domain |
| Domain | IPR020635 | Tyrosine-protein kinase, catalytic domain |
| Family | IPR050198 | Non-receptor tyrosine kinases involved in cell signaling |
| Homologous_superfamily | IPR011009 | Protein kinase-like domain superfamily |
| Homologous_superfamily | IPR011993 | PH-like domain superfamily |
| Homologous_superfamily | IPR036028 | SH3-like domain superfamily |
| Homologous_superfamily | IPR036860 | SH2 domain superfamily |
Domain Details Per Protein
| Protein | Length | Non-receptor tyrosine kinases involved in cell signaling | PH-like domain superfamily | Pleckstrin homology domain | Protein kinase, ATP binding site | Protein kinase domain | Protein kinase-like domain superfamily | Serine-threonine/tyrosine-protein kinase, catalytic domain | SH2 domain | SH2 domain superfamily | SH3 domain | SH3-like domain superfamily | Tyrosine-protein kinase, active site | Tyrosine-protein kinase, catalytic domain | Zinc finger, Btk motif |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
|
UniProtKB:O42200
|
616 |
Interactions and Pathways
No data available
Plasmids
No data available