ZFIN ID: ZDB-GENE-990415-238
Gene Name: retinal homeobox gene 3
Gene Symbol: rx3
Previous Names: chk, chokh, eyes missing (1), eym (1)
Location: Chr: 21   Details
GENE EXPRESSION
All Expression Data: 54 figures from 34 publications
Wild-type Stages, Structures: Gastrula:Shield (6.0h-8.0h) to Larval:Protruding-mouth (72.0h-96.0h, 3.5mm)
  anterior neural plate, diencephalon, forebrain, forebrain ventral region (all 17) expand
Curated Microarray Expression: GEO (1)
MUTANTS AND TARGETED KNOCKDOWNS
Mutant lines: 13 genotypes
Alleles: hu499, ne2611, rx3_unspecified, s399, t25181 (all 7) expand
Knockdown reagents: MO1-rx3 (1), MO2-rx3 (1), MO3-rx3 (1)
PHENOTYPE
Data: 13 figures from 7 publications
Observed in: adenohypophysis, adenohypophysis development, camera-type eye morphogenesis, cellular response to light stimulus (all 17) expand

Phenotype of Human Orthologue OMIM Phenotype ID
Microphthalmia, isolated 3 611038
GENE ONTOLOGY
Ontology GO Term
Biological Process adenohypophysis development (more)
Cellular Component nucleus (more)
Molecular Function DNA binding (more)
GO Terms (all 14)
PROTEIN FAMILIES, DOMAINS AND SITES
  • InterPro:IPR001356 (1)
  • InterPro:IPR003654 (1)
  • InterPro:IPR009057 (1)
  • InterPro:IPR017970 (1)
  • PROSITE:PS00027 (1)
  • PROSITE:PS50071 (1)
  • PROSITE:PS50803 (1)
  • Pfam:PF00046 (1)
  • Pfam:PF03826 (1)
  • TRANSCRIPTS
    Type Name Length (bp) Analysis
    mRNA rx3-001 (1) 1411
    GENE PRODUCT DESCRIPTION
    ANTIBODIES No data available
    PLASMIDS No data available
    CONSTRUCTS WITH SEQUENCES FROM rx3 No data available
    SEGMENT (CLONE AND PROBE) RELATIONSHIPS
    rx3 Contained in: [BAC] CH211-233A1 (1) (order this)
    rx3 Encodes: [cDNA] MGC:195183 (1), MGC:195186 (1)
    SEQUENCE INFORMATION
    Type Accession # Length (bp/aa) Analysis
    RNA RefSeq:NM_131227 (1) 1322 bp
    Genomic GenBank:BX248399 (1) 158884 bp
    Select Tool
    Polypeptide UniProtKB:A8E7H4 (1) 292 aa
    Sequence Clusters UniGene:540 (1)
    Sequence Information (all 17)
    OTHER rx3 GENE PAGES
  • Gene:30474 (1)
  • VEGA:OTTDARG00000018942 (1)
  • Ensembl(Zv9):ENSDARG00000052893 (1)
  • ORTHOLOGY
      Evidence
    Species Symbol Chr (Position) Accession # AA CL
    Zebrafish rx3 21  
    Human RAX 18 (18q21.32)
  • OMIM:601881
  • Gene:30062
  • Mouse Rax 18 ( 39.03 cM)
  • MGI:109632
  • Gene:19434
  • Orthology Details
    CITATIONS (85)