Gene

notch1b

ID

ZDB-GENE-990415-183

Name

notch receptor 1b

Symbol

notch1b Nomenclature History

Previous Names

etID309871.5 (1)
wu:fc55e11

Type

protein_coding_gene

Location

Chr: 5 Mapping Details/Browsers

Description

Predicted to enable calcium ion binding activity and signaling receptor activity. Involved in Notch signaling pathway and hematopoietic stem cell differentiation. Acts upstream of or within several processes, including fin regeneration; nervous system development; and vasculature development. Predicted to be located in membrane and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in plasma membrane. Is expressed in several structures, including cardiovascular system; digestive system; hematopoietic multipotent progenitor cell; nervous system; and trunk. Human ortholog(s) of this gene implicated in Adams-Oliver syndrome; adult T-cell leukemia/lymphoma; and aortic valve disease 1. Orthologous to human NOTCH1 (notch receptor 1).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

175 figures from 118 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

eu523 (10 images)

Wild Type Expression Summary

Phenotype

All Phenotype Data: 14 figures from 12 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With notch1b Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
Adams-Oliver syndrome	Alliance	Adams-Oliver syndrome 5	616028
aortic valve disease 1	Alliance	Aortic valve disease 1	109730

Associated With notch1b Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR013032	EGF-like, conserved site
Conserved_site	IPR018097	EGF-like calcium-binding, conserved site
Domain	IPR000742	EGF-like domain
Domain	IPR000800	Notch domain
Domain	IPR001881	EGF-like calcium-binding domain
Domain	IPR010660	Notch, NOD domain
Domain	IPR011656	Notch, NODP domain
Domain	IPR024600	Notch, C-terminal
Domain	IPR049883	NOTCH1 EGF-like calcium-binding domain
Family	IPR008297	Notch
Family	IPR022362	Neurogenic locus notch homolog protein 1
Family	IPR050906	Notch signaling pathway
Family	IPR051355	Notch and Slit guidance protein
Homologous_superfamily	IPR009030	Growth factor receptor cysteine-rich domain superfamily
Homologous_superfamily	IPR035993	Notch-like domain superfamily
Homologous_superfamily	IPR036770	Ankyrin repeat-containing domain superfamily
PTM	IPR000152	EGF-type aspartate/asparagine hydroxylation site
Repeat	IPR002110	Ankyrin repeat

Domain Details Per Protein

Protein	Length	Ankyrin repeat	Ankyrin repeat-containing domain superfamily	EGF-like calcium-binding, conserved site	EGF-like calcium-binding domain	EGF-like, conserved site	EGF-like domain	EGF-type aspartate/asparagine hydroxylation site	Growth factor receptor cysteine-rich domain superfamily	Neurogenic locus notch homolog protein 1	Notch	NOTCH1 EGF-like calcium-binding domain	Notch and Slit guidance protein	Notch, C-terminal	Notch domain	Notch-like domain superfamily	Notch, NOD domain	Notch, NODP domain	Notch signaling pathway
UniProtKB:A0PGH6 InterPro	2465
UniProtKB:A0A8M2BFY6 InterPro	2482

Transcripts

Genome Browsers

Type	Name	Annotation Method	Length (nt)	Analysis
mRNA	notch1b-201 (1) Ensembl	Ensembl	7,781 nt	Select Tool ZFIN BLAST
mRNA	notch1b-202 (1) Ensembl	Ensembl	7,824 nt	Select Tool ZFIN BLAST
mRNA	notch1b-203 (1) Ensembl	Ensembl	2,314 nt	Select Tool ZFIN BLAST

Interactions and Pathways

SignaFish

Antibodies

No data available

Plasmids

No data available

Constructs

Marker Relationships

Sequences

Orthology

Comparative Orthology: Alliance
Gene Tree: Ensembl

Citations