ndr2

ID

ZDB-GENE-990415-181

Name

nodal-related 2

Symbol

ndr2 Nomenclature History

Previous Names

Ndr-2
cyc-1 (1)
cyc (1)
cyclops (1)
Znr-1
znr1

Type

protein_coding_gene

Location

Chr: 12 Mapping Details/Browsers

Genome Assembly

GRCz12tu

Annotation Status

Current

Description

Predicted to enable cytokine activity. Acts upstream of or within several processes, including embryonic morphogenesis; nervous system development; and regionalization. Part of protein-containing complex. Is expressed in several structures, including axis; embryonic structure; forebrain; forebrain neural keel; and mesoderm. Human ortholog(s) of this gene implicated in visceral heterotaxy 5. Orthologous to human NODAL (nodal growth differentiation factor).

Genome Resources

Note

None

Comparative Information

Expression

All Expression Data

65 figures from 52 publications

Cross-Species Comparison

High Throughput Data

GEO (1)

Expression Atlas

UO scRNA-seq (UCSC browser)

Single Cell Expression Atlas

Daniocell

Thisse Expression Data

No data available

Wild Type Expression Summary

Phenotype

All Phenotype Data: 25 figures from 17 publications
Cross-Species Comparison: Alliance

Phenotype Summary

Mutations

Mutants

Sequence Targeting Reagents

Human Disease

Associated With ndr2 Human Ortholog

Disease Ontology Term	Multi-Species Data	OMIM Term	OMIM Phenotype ID
visceral heterotaxy 5	Alliance	Heterotaxy, visceral, 5	270100

Associated With ndr2 Via Experimental Models

No data available

Gene Ontology

Protein Domains

Domain, Family, and Site Summary

Type	InterPro ID	Name
Conserved_site	IPR017948	Transforming growth factor beta, conserved site
Domain	IPR001111	TGF-beta, propeptide
Domain	IPR001839	Transforming growth factor-beta, C-terminal
Family	IPR015615	Transforming growth factor-beta-related
Homologous_superfamily	IPR029034	Cystine-knot cytokine